Omega-3 Research

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Under Pressure

But even if you’re prepared for the effort and expense, the benefits of repairing intrinsically flawed connections in the brain may be limited. The clearest indication of this came in 2001, in a study led by Dr Richard Weisinger of the University of Melbourne, Australia.

Weisinger’s team showed that laboratory rats deprived of essential fatty acids at specific stages in their development developed high blood pressure that remained elevated for the rest of their lives. The brain’s control over the autonomic nervous system and cardiovascular system was permanently affected.

However, studies such as the Durham trial suggest that all is not lost, and that boosting Omega 3 intake may still confer significant benefits.

The Omega 3 fatty acid used in the Durham trial was Eicosapentaenoic acid (EPA). It may play an equally crucial role in brain function. EPA is found only at very low levels in the cell membranes; it seems to have a functional, rather than a structural role.

“It can improve brain function at the very simplest level, by improving blood flow,” says Richardson.

EPA helps the body manufacture important, hormone-like substances called eicosanoids. Some of these substances help improve blood flow around the body. They also seem to have controlling effects on hormones and the immune system, both of which are known to affect brain function.

Western diets contain very little Omega 3 fatty acid. Hydrogenation, the process used to give foods a long shelf life, removes them. But certain people may break down Omega 3 fatty acids faster than others. Some of the children who showed greatest improvement in the Durham trial might fall into this category.

But there is disagreement over which Omega 3 fatty acid would perform best as a treatment. US researchers such as Hibbeln tend to favour DHA, while British researchers, of which Richardson is one, mostly regard EPA as the best option.

But some quarters of the medical research community are deeply sceptical about the usefulness of so-called complementary therapies - the category of treatment in which fish oil supplements are often lumped.

Professor Richard Olson, a developmental psychologist at the University of Colorado, Boulder and an expert on the treatment of dyslexia, urged caution over a ‘quick fix’ syndrome towards the treatment of learning disorders.

“I haven’t read the research, but I have a slight feeling of unease because in the field of dyslexia particularly, one quick fix after another seems to pop up and then fall by the wayside,” says Olson.

“I hope they’re right. I’m just sceptical of easy answers because there have been various schemes in the past and parents [with dyslexic children] go out and spend a lot of money on them. For many children with dyslexia, improvement can only be achieved with a lot of hard work,” he adds.


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Recent Omega-3 Research

Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder.

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