Benefits of Fish Oil and Omega 3



General Health and Well-being

In addition to supporting mood, cognitive function, healthy blood sugar levels, increased brain neuroprotective molecules, and support for healthy neurological development and function at all ages, OmegaBrite’s essential high EPA plus the 7:1 ratio of EPA to DHA provides omega-3’s for overall good health! Other areas, such as eye health, pulmonary function, hormonal function, and healthy weight have been shown to be supported by omega-3s. The high EPA omega-3 nutrient in OmegaBrite provides you with the body’s natural anti-inflammatory molecule to support overall health and well-being.

We welcome you to experience the OmegaBrite difference today.

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Eur Neuropsychopharmacol. 2007 May-Jun;17(6-7):440-7., Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial., Wozniak J, Biederman J, Mick E, Waxmonsky J, Hantsoo L, Best C, Cluette-Brown JE, Laposata M., Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02138, USA.

Nutr Neurosci. 2007 Feb-Apr;10(1-2):1-9., Plasma, red blood cells phospholipids and clinical evaluation after long chain omega-3 supplementation in children with attention deficit hyperactivity disorder (ADHD)., Germano M, Meleleo D, Montorfano G, Adorni L, Negroni M, Berra B, Rizzo AM., NPI L R.C.S. Casa Sollievo della Sofferenza S. Giovanni R. (FG), Milan, Italy.

J Dev Behav Pediatr. 2007 Apr;28(2):82-91., Effect of Supplementation with Polyunsaturated Fatty Acids and Micronutrients on Learning and Behavior Problems Associated with Child ADHD., Sinn N, Bryan J., From *Commonwealth Scientific and Industrial Reasearch Organization Human Nutrition, Adelaide, South Australia; and daggerUniversity of South Australia, School of Psychology, Adelaide, South Australia.

Biol Psychiatry. 2007 Feb 15;61(4):551-3, Omega-3 Fatty Acids Supplementation in Children with Autism: A Double-blind Randomized, Placebo-controlled Pilot Study., Amminger GP, Berger GE, Schafer MR, Klier C, Friedrich MH, Feucht M., Department of Child and Adolescent Neuropsychiatry, Medical University of Vienna, Vienna, Austria; ORYGEN Research Centre, University of Melbourne, Melbourne, Australia.

Am J Psychiatry. 2006 Jun;163(6):1098-100., Omega-3 treatment of childhood depression: a controlled, double-blind pilot study., Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH., Faculty of Health Sciences, Ben Gurion University of the Negev, Israel.

Oxford-Durham Study, Richardson AJ, Montgomery P. The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics. 2005 May;115(5):1360-6.

Nutr J. 2007 Jul 13;6(1):16 [Epub ahead of print], Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder., Sorgi PJ, Hallowell EM, Hutchins HL, Sears B.

Eur J Clin Nutr. 2007 Oct 24; [Epub ahead of print], The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women., Muthayya S, Dwarkanath P, Thomas T, Ramprakash S, Mehra R, Mhaskar A, Mhaskar R, Thomas A, Bhat S, Vaz M, Kurpad AV., Division of Nutrition, Maternal and Child Health Unit, St John’s Research Institute, St John’s National Academy of Health Sciences, Bangalore, India.

Am J Clin Nutr. 2007 Jun;85(6):1572-7., Maternal consumption of a docosahexaenoic acid containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo., Judge MP, Harel O, Lammi-Keefe CJ., Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.

FOOD NEWS MARCH 2000, OMEGA-3 FATTY ACIDS, by Mary Ryzner, MS, RD Clinical Dietitian

Lancet. 2007 Feb 17;369(9561):578-85., Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study., Hibbeln JR, Davis JM, Steer C, Emmett P, Rogers I, Williams C, Golding J., Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA.

Lipids. 2007 Mar;42(2):117-22. Epub 2007 Jan 19., A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age., Judge MP, Harel O, Lammi-Keefe CJ., Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USA.

Early Hum. Dev. 2007 May;83(5):279-84., Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula., Birch EE, Garfield S, Castañeda Y, Hughbanks-Wheaton D, Uauy R, Hoffman D., Retina Foundation of the Southwest, Dallas, TX 75231, USA.

Arch Dis Child Fetal Neonatal Ed. 2006 Dec 21; [Epub ahead of print], Cognitive assessment at 21/2 years following fish oil supplementation in pregnancy: a randomized controlled trial., Dunstan JA, Simmer K, Dixon G, Prescott SL., University of Western Australia, Australia.

Am. J. Clin. Nutr. 2005 Apr;81(4):871-9., Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo., Birch EE, Castañeda YS, Wheaton DH, Birch DG, Uauy RD, Hoffman DR., Retina Foundation of the Southwest, Dallas, TX, USA.

Am. J. Clin. Nutr. 2005 Jul;82(1):125-32., Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants.

Jensen CL, Voigt RG, Prager TC, Zou YL, Fraley JK, Rozelle JC, Turcich MR, Llorente AM, Anderson RE, Heird WC.

US Department of Agriculture/Agricultural Research Service Children’s Nutrition Research Center and the Meyer Center for Developmental Pediatrics, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Helland, I. B., L. Smith, et al. (2003). “Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age.” Pediatrics 111(1): e39-44.

Am. J. Clin. Nutr. 2003 Aug;78(2):313-8., Long-chain polyunsaturated fatty acids have a positive effect on the quality of general movements of healthy term infants., Bouwstra H, Dijck-Brouwer DA, Wildeman JA, Tjoonk HM, van der Heide JC, Boersma ER, Muskiet FA, Hadders-Algra M., Department of Neurology, University of Groningen, Groningen, The Netherlands.

Pediatr. 2003 Jun;142(6):669-77., Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial., Hoffman DR, Birch EE, Castañeda YS, Fawcett SL, Wheaton DH, Birch DG, Uauy R., Retina Foundation of the Southwest, Dallas, Texas 75231, USA.

Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):327-35. Epub 2007 Nov 26., Immunomodulation by omega-3 fatty acids., Calder PC.

Am J Clin Nutr. 2002 Mar;75(3):570-80., A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age., Birch EE, Hoffman DR, Castaneda YS, Fawcett SL, Birch DG, Uauy RD., Retina Foundation of the Southwest, Dallas, TX 75231, USA.

Surette, M. E., I. L. Koumenis, et al. (2003). “Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo-controlled, parallel-group, prospective trial.” Clin Ther 25(3): 972-9.

Chest. 2006 Jan;129(1):39-49., Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma., Mickleborough TD, Lindley MR, Ionescu AA, Fly AD., Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, 1025 E Seventh St, HPER 112, Bloomington, IN 47401, USA.

J Asthma. 2005 Jun;42(5):305-14., Dietary omega-3 polyunsaturated fatty acid supplementation and airway hyperresponsiveness in asthma., Mickleborough TD., Department of Kinesiology, Indiana University, Bloomington, Indiana 47401, USA.,

Eur Respir J. 2000 Nov;16(5):861-5., Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma., Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K., Dept of Paediatrics, Jikei University School of Medicine, Tokyo, Japan.

Nelson, J. L., S. J. DeMichele, et al. (2003). “Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants on antioxidant status in patients with acute respiratory distress syndrome.” JPEN J Parenter Enteral Nutr 27(2): 98-104.

Mikhail, A. T., T. A. Babcock, et al. (2003). “Modulation of the ubiquitin-proteasome proteolytic pathway by eicosapentaenoic acid supplementation in a model of progressive malignancy.” JPEN J Parenter Enteral Nutr 27(2): 105-9.

James, M. J., V. M. Ursin, et al. (2003). “Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids.” Am J Clin Nutr 77(5): 1140-5.

Horrobin, D. F. (2003). “A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels.” Med Hypotheses 60(5): 615-23.

Hida, M., H. Fujita, et al. (2003). “Eicosapentaenoic acid inhibits PDGF-induced mitogenesis and cyclin D1 expression via TGF-beta in mesangial cells.” J Cell Physiol 196(2): 293-300.

Heyd, V. L. and A. R. Eynard (2003). “Effects of eicosatrienoic acid (20:3 n-9, Mead’s acid) on some promalignant-related properties of three human cancer cell lines.” Prostaglandins Other Lipid Mediat 71(3-4): 177-88.

Fearon, K. C., M. F. Von Meyenfeldt, et al. (2003). “Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial.” Gut 52(10): 1479-86., Erkkila, A. T., S. Lehto, et al. (2003). “n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary

Effects of highly purified eicosapentaenoic acid on erythrocyte fatty acid composition and leukocyte and colonic mucosa leukotriene B4 production in children with ulcerative colitis., Shimizu T, Fujii T, Suzuki R, Igarashi J, Ohtsuka Y, Nagata S, Yamashiro Y., Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan.

Ross, J. A., J. P. Maingay, et al. (2003). “Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells.” Int J Oncol 23(6): 1733-8.

Rhodes, L. E., H. Shahbakhti, et al. (2003). “Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.” Carcinogenesis 24(5): 919-25.

Chen, H., D. Li, et al. (2003). “Eicosapentanoic acid inhibits hypoxia-reoxygenation-induced injury by attenuating upregulation of MMP-1 in adult rat myocytes.” Cardiovasc Res 59(1): 7-13.

BMC Ophthalmol. 2007 Feb 26;7:3., TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD., Cangemi FE., Vitreo-Retinal Associates of New Jersey, Ridgewood, New Jersey 07450, USA.

Int J Geriatr Psychiatry. 2007 Jun 21; [Epub ahead of print], Omega-3 supplementation in mild to moderate Alzheimer’s disease: effects on neuropsychiatric symptoms., Freund-Levi Y, Basun H, Cederholm T, Faxn-Irving G, Garlind A, Grut M, Vedin I, Palmblad J, Wahlund LO, Eriksdotter-Janhagen M., Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden., Chem. Biol. Interact. 2006 Aug 25;162(2):89-105. Epub 2006 May 27., Nutritional intervention with omega-3 fatty acids enhances tumor response to anti-neoplastic agents., Pardini RS., Department of Biochemistry, University of Nevada, Reno, NV 89557, USA.

Support Care Cancer. 2005 Apr;13(4):270-4. Epub 2004 Dec 4., Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy–a pilot study., Bauer JD, Capra S., The Wesley Research Institute, PO Box 499, Toowong, Queensland, Australia 4066.

Nutrition. 2005 Jun;21(6):639-49., Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer., Nakamura K, Kariyazono H, Komokata T, Hamada N, Sakata R, Yamada K., Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Int. J. Cancer. 2004 Sep 10;111(4):611-6., Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients., Heller AR, Rössel T, Gottschlich B, Tiebel O, Menschikowski M, Litz RJ, Zimmermann T, Koch T., Department of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany.

Bone Marrow Transplant. 2001 Oct;28(8):769-74., Oral eicosapentaenoic acid for complications of bone marrow transplantation., Takatsuka H, Takemoto Y, Iwata N, Suehiro A, Hamano T, Okamoto T, Kanamaru A, Kakishita E., Second Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.

Nutr. 1999 Jun;129(6):1120-5., Fish oil-enriched nutritional supplement attenuates progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer., Barber MD, Ross JA, Preston T, Shenkin A, Fearon KC., University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, United Kingdom.

Am J Gastroenterol. 2007 Jul 7; [Epub ahead of print], Imbalances in Dietary Consumption of Fatty Acids, Vegetables, and Fruits Are Associated with Risk for Crohn’s Disease in Children., Amre DK, D’Souza S, Morgan K, Seidman G, Lambrette P, Grimard G, Israel D, Mack D, Ghadirian P, Deslandres C, Chotard V, Budai B, Law L, Levy E, Seidman EG., Department of Pediatrics, University of Montreal, Montreal, Canada

Clin. Chim. Acta. 2006 Nov;373(1-2):1-8. Epub 2006 May 16., Omega-3 fatty acid effects on biochemical indices following cancer surgery, Stehr SN, Heller AR., Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Fetscherstrasse 74, D-01309 Dresden, Germany.

JAMA. 2007 Sep 26;298(12):1420-8., Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes., Norris JM, Yin X, Lamb MM, Barriga K, Seifert J, Hoffman M, Orton HD, Barón AE, Clare-Salzler M, Chase HP, Szabo NJ, Erlich H, Eisenbarth GS, Rewers M., Department of Preventive Medicine and Biostatistics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA.

BioDrugs. 1999 Apr;11(4):285-91., Fish oil treatment of interferon-alpha-induced dyslipidaemia: study in patients with chronic hepatitis C., Malaguarnera M, Restuccia N, Fazio ID, Panebianco MP, Gulizia G, Giugno I., Department of Internal Medicine and Geriatrics, University of Catania, Italy.

Chisaki, K., Y. Okuda, et al. (2003). “Eicosapentaenoic acid suppresses basal and insulinstimulated endothelin-1 production in human endothelial cells.” Hypertens Res 26(8): 655, 61.

Neurology. 2007 Nov 13;69(20):1921-30., Dietary patterns and risk of dementia: The Three-City cohort study., Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, Alprovitch A., INSERM, U593, University Victor Segalen Bordeaux 2, case 11, 146 rue Lo-Saignat, F-33076 Bordeaux cedex, France.

J Neurotrauma. 2007 Oct;24(10):1587-95., Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury., Wu A, Ying Z, Gomez-Pinilla F., Department of Physiological Science, University of California at Los Angeles(UCLA), Los Angeles, California 90095, USA.

FASEB J. 2007 Nov 21 [Epub ahead of print], Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson’s disease., Bousquet M, Saint-Pierre M, Julien C, Salem N Jr, Cicchetti F, Calon F.

Epilepsy Behav. 2007 Dec 6 [Epub ahead of print], Erythrocyte and plasma fatty acid profiles in patients with epilepsy: Does carbamazepine affect omega-3 fatty acid concentrations, Yuen AW, Sander JW, Flugel D, Patsalos PN, Browning L, Bell GS, Koepp MM., Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; National Society for Epilepsy, Chalfont St. Peter, Bucks, UK.

BioDrugs. 1999 Apr;11(4):285-91., Fish oil treatment of interferon-alpha-induced dyslipidaemia: study in patients with chronic hepatitis C., Malaguarnera M, Restuccia N, Fazio ID, Panebianco MP, Gulizia G, Giugno I., Department of Internal Medicine and Geriatrics, University of Catania, Italy.

Dig Liver Dis. 2007 Dec 2 [Epub ahead of print], Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease., Spadaro L, Magliocco O, Spampinato D, Piro S, Oliveri C, Alagona C, Papa G, Rabuazzo AM, Purrello F., Department of Internal Medicine, Ospedale Garibaldi-Nesima, University of Catania, Italy.

J Clin Psychiatry. 2007 Dec;68(12):1867-75., Ethyl-eicosapentaenoic acid in first-episode psychosis: a randomized, placebo-controlled trial., Berger GE, Proffitt TM, McConchie M, Yuen H, Wood SJ, Amminger GP, Brewer W, McGorry PD., ORYGEN Research Centre (incorporating the Early Psychosis Prevention and Intervention Centre [EPPIC]), University of Melbourne, Australia.

Neuropsychopharmacology. 2008 Jan 16 [Epub ahead of print], Ethyl-Eicosapentaenoic Acid in First-Episode Psychosis. A 1H-MRS Study., Berger GE, Wood SJ, Wellard RM, Proffitt TM, McConchie M, Amminger GP, Jackson GD, Velakoulis D, Pantelis C, McGorry PD., [1] 1Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia [2] 2Department of Research & Education, The Schloessli Clinic, Oetwil am See, Zuerich, Switzerland [3] 3Howard Florey Institute, The University of Melbourne, Parkville, Australia.